Altered motor system function in post-concussion syndrome as assessed via transcranial magnetic stimulation

Altered motor system function in post-concussion syndrome as assessed via transcranial magnetic stimulation

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Objective: It is unclear why specific individuals incur chronic symptoms following a concussion.This exploratory research aims to identify and characterize any neurophysiological differences that may exist in motor cortex function in post-concussion syndrome (PCS).Methods: Fifteen adults with PCS and 13 healthy, non-injured adults were tested.

All participants completed symptom questionnaires, and transcranial magnetic stimulation (TMS) was used to measure intracortical and transcallosal excitability and inhibition in the dominant bostik mvp motor cortex.Results: Cortical silent period (p = 0.02, g = 0.

96) and ipsilateral silent period (p = 0.04, g = 0.78) were shorter in the PCS group compared to the control group which may weleda skin food 75ml best price reflect reduced GABA-mediated inhibition in PCS.

Furthermore, increased corticomotor excitability was observed in the left hemisphere but not the right hemisphere.Conclusions: These data suggest that persistent neurophysiological differences are present in those with PCS.The exact contributing factors to such changes remain to be investigated by future studies.

Significance: This study provides novel evidence of lasting neurophysiological changes in PCS.